Compound of silver and formonucleinic acid.



NETE@ STATES PATENT FFCE. erro nnoNnR, `or RLBRRRELD, oiiRi-iANY, AssiGNoR To FARBENRABRI- inni voRM. reino-R. BAYER a oo., or ELBERFRLD, GERMANY, A ooR- POitiTiON OF GERMANY;

COMPQLJND OF SlLi/ER AND FORMONCLEIINUC ACID.

ne. stesso.

Specification of Letters Patent.

Patented Mayf?, 1907.

Application led April 17, '3.906. Serial No. 312,176.

1'0 (t/1 who/l1, it IIL/1.1,'ran/warn.-

le it lrnown that l, Orro DEGNER, doctor ol philosophy, chemist, a citizen of the German Empire, residing at Elberfeld, Ger- 5 many, Kingdom oi' Prussia, have invented new and use'l'ul improvements in Compounds of Silver and Fornionucleinic Acids, oi which the following is aspeci'lication.

My invention relates `to the'productnm of lo new soluble compounds of formonucleinic acids and silver. rationoi these bodies consists in treating the ,insoluble silver compounds of fornionucleinic acids 'lor salts thereof with neutral-salt solui 5 tions.

Under the expression iorrnonucleinic acids l understand the products which are obtained by the action of forniic aldehyd on nucleinioacids of animal or vegetable origin, as they are obtained e. g. from yeast, sperm, thynius etc. The preparation of these orinonucleinicacids is ldescribed in British Letters Patent 11882 oi' 1902.

The new silver compounds are ofhigh percentago. T hey contain more than per cent. of silver e. g. 'from 15 to 25 per cent.-

They are, when dry and pulverized, yellowish powders soluble in water with a yellowish brown color and insoluble in either and ben- 39' Zeno. They contain the silver so iirmly conibined with the lorinonucleinic acid molecule that on adding a diluted solution of caustic soda lye or a solution ol common salt to the aqueous solution ol the new silver compounds no precipitate is obtained. The new products possess valuable therapeutic properties as autise'pticsand their `freedom from irritation renders their outward application highly satisfactory. A solution ol from 2 to 49 3 per cent. may be used i or external application.

ln carrying out my new process practically loan proceed as follows, the parts being by weight:

Example l. l0 parts of silver nitrate dissolved in water are stirred into a solution of 100 parts 'ot' the sodium salt oi i'orinonucleinic acid from yeast in 300 parts oi water. A voluminous precipitate .is obtained to which 5.o a saturated solution o'lfr-,oinmon salt is slowly added until a clear solution results. 'lhe soluble silver compound thus obtained is separate-:i lroni its solution by the addition of The process -for the prepawith alcohol and dried in. vacuo. It is a yellowish-white powder having the above menalcohol, filtered oil', washed several times 55 n tioned properties and containing about 22 per cent. of silver.

Example 2. 10() parts of the sodium salt of the formo-nucleinic acid from yeast are dissolved in 300 parts of Water, and to this solution SOparts of silver nitrate, dissolved in water, are added with stirring. A voluminous precipitate is obtained to which a saturated solution oii coinni'on salt is slowly added i The soluble .until a clear solution results. silver compound thus obtained is separated from the solution. by the addition of alcohol, iiltered ofl,wasl1ed several times with alcohol, and dried in occ/zio. lt' is a yellowish-white powder, having the above-mentioned proporties, and containing about 15% of silver.

Example 3. 100 parts of the sodium salt of the forrnonuoleinic acid from yeast are dissolved in 300 parts of water, and to tliissolution parts of silver nitrate, dissolved in water, arel added with stirring. -A voluminous precipitate is obtained to which a saturated solution of common salt is slowly added until a clear solution results. The soluble silver compound thus obtained is separated from the solution by theaddition of alcohol, filtered ofi, washed several times with alcohol, and dried in raeuo. It is a yellowish-white powder, having the above-mentioned properties, and containing about 25% of silver.

The process is carried out in an analogous manner on starting fromiormonucleinic acids prepared from nucleinic acids of any other origin or on using other neutral-salt solutions, such as solutions of sodium acetate, sodium nitrate, potassium chlorid etc.

Having now described iny invention and in what manner thev saine is to be performed,l

the action of'neutral-salt solutionson the in- :t

soluble silver compounds of formonucleinic aclds, which new silver compounds are, when dry andpulverized, yellowish powders soluy ble in water with a yellowish-brown color,-

insoluble in ether and benzene, and contain# ing the silver so firmly combined. with the tics, substantiallyv as described.

' The hereimdescribednew specific Silver"Y as de scri wd'. s

-In testimony whereof I have hereunto set compound of formoniicleinic leid from yeast containing. about 22 pel' cent. of silver,v obminable by the action of e common salt solution on. the insoluble silver "Compound of zfornionucleinic acid from yeast, which new silver'eoi 'poundivspvlendry and pulverized, e. yellowish powder soluble 1n Watelf with a,

yellowishbrown color, insoluble in ether and I y I Witnesses:

benzene, and containing the silver so firmly I 5 combined with the formonucleinic acid m'ole'- cule .that the aqueous solution does not giye anyprecipitate `on thek addition iof .dilute caustic soda lye or a' solution of'common salt;

and bein a-valueble antiseptic, substantially "2o my lhaind in the Ipresence of two subscribing witnesses. I

OTTO YDE (;rl\lERA OTTO KNIG, ARTHUR MATTHWs. 

